“Epigenetics” refers to mechanisms of gene expression regulation that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Epigenetic regulations play an important role in a variety of human disorders and diseases. In addition, age, environment, lifestyle, and other factors influence epigenetic states.
Epigenetic regulation of gene transcription and expression has been linked to discrete mechanisms that affect the stability, folding, positioning, and organization of DNA. The most studied of these mechanisms includes DNA methylation and chromatin remodeling, which work synergistically to organize the genome into transcriptionally active and inactive zones. This course is an introduction to epigenetics and an introduction to “epigenomics” – a study of the “epigenome”.
Specifically, we will discuss the biology and mechanisms of epigenetics. We will also start discussing lab protocols that exist to generate epigenomic data and subsequent analysis methods. To better understand these bioinformatics approaches to studying the epigenetic changes, we will start with the biology and the molecular assays that are used to research these regulatory mechanisms.
- Lectures 11
- Quizzes 3
- Duration 50 hours
- Skill level Intermediate
- Language English
- Students 3
- Certificate Yes
- Assessments Yes
What is Epigenetics
Molecular assays for studying epigenetic mechanisms
Computational approaches for analyzing epigenetic regulations